Ramelteon used to treat insomnia can reduce the occurrence of osteoporosis

Aim: Melatonin promoted osteoblast differentiation and causes an increase in levels of markers bone proliferation. Ramelteon (RAMEL) activates melatonin receptors binds to these as non-selective. In this study, we investigated the preventive effects agonist RAMEL on osteoporosis by radiological, histological, molecularly.Methods: Groups 1: Control, Group 2: Osteoporosis: Overectomized group (OP), 3: OP + ramelteon 2 mg/kg, 4: 4 mg/kg. 24 animals underwent bilateral ovariectomy. was administered orally once a day prophylactic treatment mode for 8 weeks, 6 weeks after ovariectomy.Results: Fourteen ovariectomy, there significant reduction femoral mineral density (BMD) (g/cm2) compared control group. Compared group, significantly increased BMD level (p<0.05). Bone matrix protein (BMP2) runt-related transcription factor (RUNX2) mRNA were lower than RUNX2 BMP2 higher groups (p<0.05).Conclusion: To take advantage peripheral melatonin, RAMEL, agonist, can be used prevent osteoporosis.